Patient Case Study 2

PCR for Urinary Tract Infections
Before PCR Testing

Shirley, an 82-year-old female with a previous history of pelvic wall/floor collapse/prolapse and frequent and chronic recurrent UTI’s, required bladder mesh surgery.

Shirley developed a UTI, and antibiotics were administered. Culture and sensitivity testing was ordered, and Shirley was hospitalized after 3-4 days with fever and worsening symptoms.

Another urinalysis was performed, which confirmed a UTI, and creatinine was high upon Shirley’s admission to hospital. Another culture and sensitivity test was ordered. Results of both culture and sensitivity tests were inconclusive.

Shirley was treated with systemic antibiotics and released after creatinine came back down to normal in 5 days.

PCR for Urinary Tract Infections
After PCR Testing

Within 2 weeks, Shirley became symptomatic with a recurrent UTI. Her urinalysis was positive, and she was started on an antibiotic, cephalexin.

Shirley’s symptoms did not improve, and PCR testing was performed. It was confirmed that the recurrent UTI was a result of E. coli. Antimicrobial resistance to cephalexin was reported on the HealthTrackRx PCR Personalized Antibiogram, and Shirley was placed on twice daily nitrofurantoin.

Shirley’s symptoms resolved; however, her hospitalization could easily have been prevented.